The purpose of this study is to develop the bilayer tablet of paracetamol where first layer is immediate release and the second layer is extended release for better, longer symptomatic relief. The immediate release layer of tablet was prepared by wet granulation while the extended release layer was directly compressed matrix layer. The ingredients for preparation of granules of immediate release layer were selected by trial and error method. While the extended release matrix was optimized by different ratio of HPMC K4M and xanthan gum. The tablets were analyzed to determine their hardness, friability, uniformity of weight, uniformity of content and in vitro dissolution study. The formulation batch F3 was found to be optimum. More than half of the dose was immediately released and extended release was achieved for the remaining dose. The extended release was achieved with the developed combination matrix systems based on HPMC and xanthan gum. HPMC may start retarding the release of the drug comparatively faster than xanthan gum. In opposite side the xanthan gum is responsible for the longer retardation. The tablets of F3 formulation batch was found to deliver the drug consistently for the required period of time. The extended release was found to follow the non – fickian release pattern.
Loading....